SUPPOSE A PATIENT IS BROUGHT INTO YOUR CLINIC IN A HYPOGLYCEMIC STATE WITH A BLOOD GLUCOSE OF 3.5MM. THE PATIENT IS DISORIENTED AND SLURRING HIS SPEECH AND FEELING WOOZY.
THE KT FOR GLUT1, EXPRESSED IN BRAIN CELLS, IS 1.5MM. THE KM FOR THE HEXOKINASE I, EXPRESSED IN BRAIN CELLS, IS 0.1MM. WHAT IS THE VELOCITY OF TRANSPORT INTO THESE CELLS AS A PERCENTAGE OF VMAX? WHAT IS THE VELOCITY OF GLUCOSE 6-PHOSPHATE PRODUCTION IN THESE CELLS AS A PERCENTAGE OF VMAX? WHICH OF THESE PROTEIN ACTIVITIES EXPLAINS THE SYMPTOMS IN THE PATIENT?
Suppose a patient is brought into your clinic in a hypoglycemic state with a blood glucose of 3.5mM. The patient is disoriented and slurring his speech and feeling woozy. The Kt for GLUT1, expressed in brain cells, is 1.5mM. The Km for the hexokinase I, expressed in brain cells, is 0.1mM. What is the velocity of transport into these cells as a percentage of Vmax? What is the velocity of glucose 6-phosphate production in these cells as a percentage of Vmax? Which of these protein activities explains the symptoms in the patient?
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